Ideas, come on down!

A little cloudy.
Yesterday I got the flu vaccine, which is not as painful as the new coronavirus vaccine.
It's not a muscle shot, so that's not surprising, but it's still very different.

As usual, time is running out.
I have to give a small talk tomorrow, and I have to submit my slides for the talk in advance, which are due by the end of this week.
I had hoped that this week would be a bit of a mountain and I would be able to come up with something when the time came, but I have not been able to come up with any ideas.
I have woken up in the middle of the night many times in the past few days thinking about the content of my talk, but nothing has come to mind.

The concept of the disease has not settled down, and the introduction of genetic analysis has made the story of a few years ago even more complicated.
The points of discussion are now mixing gross and microscopic findings with genetic information, and the question is what is most important for diagnosis.

Gross findings, including imaging findings, are most important for direct access to the lesion, especially for surgical treatment.
However, the microscopic findings that we pathologists observe and diagnose are necessary to consider the development and progression of the disease, and in the past, the combination of gross and microscopic findings was sufficient to identify most diseases.
However, with the advent of genetic analysis, this trend has changed drastically.
Even if the disease looks the same to the naked eye and microscopically, the pathogenesis of the disease may differ depending on the type of genetic abnormality.
Even if the treatment is the same and the findings are the same, it means that we do not know what will happen in the future.

I was just summarizing what I'm going to talk about and my thoughts started to fall a little bit, so I'm going to stop writing today's blog and start working on tomorrow's slides.